I would definitely focus on personality more than breed. If you go to a rescue, you can usually spend quite a bit of time with a lot of different bunnies and see which one fits you best. Some are gonna want to explore everything, while other will be couch potatoes with you. Depends on what you are looking for in a bun.
The only really concern I had regarding breeds was size like Sleepy said (I wanted something bigger). I’ve read that smaller buns are less likely to deal well being picked up, and aren’t big cuddlers (again I’m sure this varies and some won’t mind it.). While some of the bigger ones don’t mind it as much. Also, a bun’s size will have an impact on the cage size, and amount of food they’ll be eating (especially if you’re going for a giant breed).
The awesome thing about going to a rescue, is they can usually tell you about the personalities and point you in the direction of a bun that’ll fit what you’re looking for.
Here’s a link to a list of breeds by size:
http://exoticpets.about.com/cs/rabb…eeds_3.htm