How long has it been since the spay? Girl rabbits often go through hormonal fluctuations with accompanying mood swings for quite som time after a spay. Boys go through a similar phase after a neuter, but it generally lasts a much shorter time in boys.
There are also changes that happen when a bun becomes an adult, regardless of having been spayed or not. Baby bunnies are trusting and cuddly, teenage/young adult buns are more skittish and wary. This mellows out too, to a larger or lesser extent, but it’s a normal phase that I think all mammals (and some birds) go through. You may have heard of the “spook age” in young dogs, when they can be spooked by pretty much anything, like a tree or a paper bag etc. Basically it’s about a process where the animal is learning to fend for itself as an adult, and being very wary is vital for survival in the wild.
Is she eating and pooping like normal? (Things to always keep an eye on, because health issues tend to manifest in loss of appetite and/or weird poop in rabbits).