I just drove from CA to MA with my bunnies (6 days of driving) and they handled it really well. My vet thought that driving was the better option because we would have more control over the situation (like being able to stop when needed, syringe feeding, etc.).
BUT we would have had at least 1 stop over flying, and we have four rabbits, so it was going to be rough to fly as well.
The thing that’s annoying with flying is that only a few airlines allow bunnies in the cabin. Planes are also very new to rabbits, and sometimes the pressure-changes can be stressful to them, whereas most bunnies have been in a car before so they are a bit more familiar with it.
In you case, if you drive, I would split it over two days. Or you could fly and get it over with pretty quickly. I think in either case it would be fine, so whichever works best for you.
.
.
.
The answers provided in this discussion are for general guideline purposes only. The information is not intended to diagnose or treat your pet. Seek the advice of your veterinarian or a qualified behaviorist.