OK, thanks for the additional info. They may or may not be able to do a needle biopsy. I guess it would depend on the consistency of the mass. Your description does suggest a cancerous tumor. Lipomas can sometimes grow rapidly as well.
Yes, if the tumor grows very rapidly, it can grow faster than the skin can accommodate… leading to rupture. You don’t see it as often in rabbits, but it can happen. It sounds like this one has been growing for a couple of months, so it may not be growing fast enough for the skin to not keep up with it.
If this is cancer, I would think that reduced mobility due to tumor size would be the least of your worries. Did the vet do any other x-rays or imaging? If this tumor is coming from a lymph node then it’s possible the cancer started somewhere else in the body and then metastasized to the lymph node. I’m just wondering if your bunny has had cancer for some time now and it is just now showing externally (i.e. with this tumor).
You can make him comfortable by just making sure he has everything he needs. Perhaps offering him his favorite foods on a regular basis will encourage him to eat and make him happy at the same time. I doubt the antibiotic was making him drowsy, it was probably the pain med. You could try a different dose, giving it before his normal nap time, or splitting the dose. Your vet should be able to advise you on that. His quality of life is most important right now, so keep a close eye for signs of him declining – Lethargy, lack of appetite, etc.
I’m sorry you’re having to go through this. It’s an awful feeling of knowing you can’t really do much for them except keep them comfortable.