I have a boy with chronic EC, not just acute flare-ups. It’s not in neurological symptoms, but his are urinary and gut related. Something triggers him and he’ll need two rounds of EC meds back to back. So 48 days total. EC can never truly be cured because it is a parasite.
In my year of dealing with Bombur’s EC, I can tell you patience is key. Sometimes it does take multiple rounds of the drug for it to work, but eventually you’ll see progress maybe at week 5 or 6, and you’ll know that you’re doing the right thing. You might ask to go on a stronger EC medicine such as Oxibendazole (Bombur takes this and sees good results). Oxibendazole is actually able to pass through the blood brain barrier making it a little more effective. If he’s on Oxibendazole he will need to be blood tested every 2 weeks to ensure his white blood cell count remains stable. I’m confused about the Ponazuril, because from what I know of it, it is used to treat Coccida. I’ve never heard of it being used to treat EC.
All this being said, you’d never know Bombur had an active chronic disease. He still runs around, pigs out on food, and flops contently. He’s a bit on the dopey side, but aside from that he’s still the same as ever. I think even for buns with neurological symptoms, if they remain with a head tilt, most of them still have a good quality of life and are very happy and seemingly healthy bunnies.