It really depends on the buns I think. Eventually you do need to work with all 4 at once, but it can be helpful to work with the pairs separately to get a sense of which combo is likely to be the most challenging. If you have someone to help you manage the sessions you could try all 4 at once to start, but you may find it less stressful to try the combos first just so you don’t end up with a giant bunny tornado.
When you do work with all 4, I recommend using a very large space, at least 2 or 3 x-pens linked up.
I would also recommend doing some pre-bonding (side by side living) before starting sessions, but be prepared for the current pair to split up. It may not happen, but it’s good to be ready with another pen just in case.
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The answers provided in this discussion are for general guideline purposes only. The information is not intended to diagnose or treat your pet. Seek the advice of your veterinarian or a qualified behaviorist.