Can you describe their set up and her interactions with her bond mate? 2 years is a bit old to be going through the teenager phase. Shy bunnies really benefit from having a lot of hides and tunnels around. One of my buns is pretty shy and wasn’t coming out to exercise until I added more hides in the exercise area.
Does she cuddle and groom with her bond mate?
Also how recently have you noticed her becoming more antisocial? My mind always goes to a source of pain, since rabbits hide things so well. There was a very antisocial bunny at the rescue, who was known to be very shy and scared, but that got worse at one point. Found out that he had liver torsion (which he fully recovered from)!
Does your cat tend to pester them? If so, having areas for them that the cat isn’t allowed should help.
Sorry for all the questions, just trying to cover all the bases!
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The answers provided in this discussion are for general guideline purposes only. The information is not intended to diagnose or treat your pet. Seek the advice of your veterinarian or a qualified behaviorist.