how long have you had her and how long ago was she spayed? It would also be helpful to know the details of her housing set up and how much exercise she gets.
Females can go through a “post-spay craze” around 3-5 weeks after being spayed as their hormones adjust. So it’s possible you are in that time window.
There are different reasons rabbits bite. Sometimes they are just exploring or testing out what things are. Sometimes they are trying to “groom you” or communicate that you are in their way. Sometimes they are fearful and defending themselves. It sounds like the attack on the paper towel roll was defensive. Rabbits sometimes get confused when you are cleaning around them and see it as an invader. The shoulder bite could have been more of a exploratory bite but it’s hard to say.
There are a couple of things to try. First, don’t clean her area while she is in it. Rabbits need to have a safe space that they feel protected in. So wait until she is not in her enclosure to clean it up. Next, when she bites you, make a loud “EEEEEK!” noise. This mimics what rabbits do when they are in pain or very afraid, and will tell her she is hurting you. The last is to wear thick gloves if she bites your hands, and don’t withdraw your hand, just keep your hand there. She will learn that biting does not make you leave.
I may have more insight once I hear what your housing situation is for her.
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The answers provided in this discussion are for general guideline purposes only. The information is not intended to diagnose or treat your pet. Seek the advice of your veterinarian or a qualified behaviorist.