I think it was good that you gave her motility drugs as prescribed. They’re not “strong” drugs, and megacolon buns might need them regularly.

Sometimes mucus in poop means overgrowth of “bad” anaerobic bacteria. I had a bun that got metronidazole for mucus-y poop. The mucus was hard and gel-like. More commonly, mucus in the stools of an adult rabbit means there’s irritation of the intestinal walls. The intestine produces mucus as a protective measure.

Pain management is extremely important for rabbits. Unfortunately meloxicam can be hard on the stomach lining. You can give famotidine (zantac) to help ameliorate this side effect, which is more common with long term use than short term. You should discuss these medical matters with your vet of course. You should also ask advice on how to fortify the diet to stop the weight loss. Other megacolon buns we’ve come across on the forums have benefitted from for example small amounts of rolled oats and pumpkin seeds.

As for the butt baths, you could perhaps try to make them somewhat nice for her. I had a poopy-butt-prone bun that I had to give butt baths often. This is how I did:

I prepared a plastic washbasin with lukewarm water and placed it on the bathroom floor. The rabbit gets less scared at floor level, because it’s floor level, and if it it does get scared and jumps out of the wash basin, the risk of harm is small.

I put my bun in the lukewarm water so he could stand in the water with his hind legs and support his front paws on the basin rim. If there was a lot of dirt stuck to the butt, I’d use a tiny bit of organic dog schampoo. Then I rinsed his behind by scooping up water with my hand. Since he stood up and was at floor level, I think he felt somewhat in control of the situation.

Post bath, I dried him off with a microfiber towel. In winter, I blow dried his butt fur with a blow dryer on a low setting. I had my free hand between the warm air outlet and the bun butt, so I could ruffle the fur and all the time make sure so it didnt get too warm. After a few times he started to really enjoy this and would often fall asleep in my lap.

Microfiber is quite a bit more effective than terry cloth or other towels. I used the type of towels they sell for dogs, they’re really great and not expensive.

All buns have their own personalities, so yes, every method must be adapted to the individual you’re dealing with.

I’ve been dealing with similar butt-bath woes with my senior who gets stuck on cecotropes and hates bum baths. And I had a foster with megacolon years ago… the mucous is so hard to deal with.

What is working well for us at the moment is to check on him routinely during the day and use baby wipes to try to get the cecals before they get mashed on. He also got a sanitary shave recently that we’ve been maintaining with a knock-off “manscaper”. It was recommended to me by a fellow bun enthusiast and it is awesome.

Often now I can put him in a towel on the counter as a burrito, and then use a wet wash cloth to clean his bum, rather than doing the full on bath. It helps a lot because the drying time is much less, and the towel prevents him from trying to jump off the counter.