My son who is twelve believes if they are different breeds they can’t communicate with each other lol) 

Hahaha! That is very cute.

I think a lot depend on the individual rabbit, to be honest. Adopting a desexed, adult rabbit through a rescue or privately is your best bet because it will already be established if they allow being handled or even enjoy being held. Some rabbits are total lap bunnies. Id even consider a blind rabbit. My experience has been they are good about being held. They are not seeing the entire room swing in all directions when being picked up.

I had a young rabbit with cataracts and he loved to sit on my lap. Then my elderly bunny, when his vision went, also sat for long periods on my lap – but he would dig and nip when he had had enough. Most of his life he disliked being picked up, until he got elderly.

Breed wise, as a general rule, the dwarf rabbits are skittish and dislike being handled. The large breed buns do better with it. There are always exceptions to the rule. Some rabbits are held a lot from day one and do well with even after they’ve reached adult hood.