I did some research on Advantage before applying it to Dawn (I found a flea on her when grooming her and went for the nuclear option immediately, because DIE FLEAS!!!!), and from what I read, Advantage isn’t toxic to rabbits. One thing I read was that if they ingest it (Like if you put it where the rabbit can lick it), it may upset their stomach. What I did, since Dawn is only 2.5 lbs, is I dosed the cat first with a “small cat” tube (And yes, that stuff comes out QUICK) and then cut the tube open and sure enough, a few drops were left in the tube ,enough to put 2 drops on Dawn.
Since your bun is roughly 4.8 lbs, I’d say it falls into the margin of error for the “5 lbs.” limit.
As far as those tubes go, I understand why they make them deliver so much so fast, as anyone who has ever tried to administer to it to a recaltrient feline can attest, but I WISH they’d change the tube design. It’s hell getting it past their hair to their skin for proper application, and if it’s delivered mostly to their fur, it doesn’t work.
What I’m going to do in the future is cut the tubes open, suck up the liquid into a syringe, and apply it that way.