Hmmm, I’ve never personally dealt with this type of behavior, but it does sound like everything she is doing is out of fear. How long have you had her? And can you describe her set-up?
I think it will be important that you don’t need to pick her up or handle her on a regular basis (only for nail trims, etc.). So you’ll want to make sure she can access her exercise area without having to be carried from a hutch or another area of the house. The fact that she reacted so badly after you moved her makes me think she is very scared of being handled, and was reacting defensively. I think it’s easy to forget that large breeds are still bunnies, and still do most things out of fear!
Other tips are to spend lots of time on the floor with her, but ignore her. Lay on the floor and read a book, etc. Play hard to get. Don’t immediately try to pet her when she approaches you. If she bites you, you can squeal (mimicking what a bunny scream sounds like) to communicate that she’s hurting you. Bunnies do communicate through nipping, and they don’t always know that they are hurting, since when they nip other bunnies they mostly just get a mouthful of fur.
Hand feed her as much as possible, again, not trying to pet right away. Make sure she has lots of safe hiding spots to retreat to. I’ve also heard it can help to leave one of your dirty socks in their pen to get them used to your scent, but I haven’t tried this myself!
Speak calmly to her as much as possible so she gets used to your voice.
I’ve had very very shy bunnies that do open up and get more calm with these strategies! I’m sure you’ll get there!
You also didn’t mention if she is spayed yet? If not she might be having some hormonal surges that are playing into things as well.
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The answers provided in this discussion are for general guideline purposes only. The information is not intended to diagnose or treat your pet. Seek the advice of your veterinarian or a qualified behaviorist.