Yes and no. You cant make a straight drive, youll have to make stops. Youll need to have them in secure carriers for driving, and a clear safe space (like a larger dog crate or pen) for them to move around. Youll need to stop every 3 hours at the absolute latest, every 1 hour is better. Each stop should be atleast 10 minutes (likely more, since you have four buns). Youll need to take them out of their litter carriers and put them in the larger safe space to allow them to move around. Offer them food, treats, veggies, water, a small litter box to toilet, etc. Once everyones had food, water, and toileted, youre good to put them back and head back onto the road. You can try to leave everyone in a large crate with food, water, and litter in it and secure the crate to ensure it doesnt move around, but a majority of rabbits, especially ones not used to long travel, do not eat or drink while the car is moving.

Have a little piece of paper with you that has vet names, hours, and phone numbers in case there is an emergency along the way. If at any point any of the rabbits refuse to eat for the entire car ride, have an emergency vet set for your final destination as its very likely the stress caused stasis.

You really shouldnt put them in a box. Everyone is going to need safe and secured carriers and atleast one large crate for free time (thats assuming they dont fight; if they do, youll need to take longer breaks with 10+ minutes each bun in the larger crate at one at a time, or more crates to have each rabbit out for their 10+ minutes all at once).

And definitely make sure your older rabbits is kept completely separate from the 6 week olds.