Hope his neuter went well.
I don’t have any experience with this myself I’m afraid, my bunnies also hate the car. I’m also not American so I have no idea what that distance is, but I assume we’re talking about at least a day of driving if you have hotels?
My general tips would be:
Get a big dog crate or something like that so he has space to stretch. Make sure litter tray etc is tied to a side so it doesn’t jolt around when you’re driving.
Bring comforting things that smell like home, eg fleece blankets or teddies.
Stop every couple of hours to give him some wet veggies so he stays hydrated. Often bunnies won’t eat in moving cars, so it’s a good idea to give them a break and check they’re eating.
Keep the temperature of the car consistent and roughly the same as your home.
Think about getting him used to radio or music as an extra comfort to drown out car noises.
I do think if it’s a long drive, hopefully he will get used to it. Lots of rabbits seem to get used to things they don’t initially like, like vacuuming or cooking noises, once they realise there’s no danger.
When you get to the new house, set him up in a small space at first, with his usual things (you might want to keep some home smelling blankets aside from the ones you use while travelling in case they get peed on during the journey!), and as he gets used to his new space you can gradually expand it
Hope others with experience can pop by!