http://wabbitwiki.com/wiki/Uterine_cancer
This is an informative article with a lot of good links in the references to scientific study. The general medical consensus is that rabbits are more prone to uterine cancer as they age. Age is the dominant factor in all the studies. Differs,t studies have different percentages, so whether it is 80 or 90 or 70, depends on the study in question. And those numbers are for rabbits 5-6 years of age. Younger rabbits have lower percentages. While I have read and been unable to find again – an article discussing uterine cancer in bred does, 99.9% of research does not cover that question as a hypothesis statement, but does say that age alone, regardless of breeding history, is the dominant factor.
It is a tough choice to make for some people, and no one can tell you what to do. Read through these articles in the reference section.
While there is risk in any surgery, the risk of a spay-gone-wrong is far lower than the alternative.