If she is not spayed, that would be my first suggestion. If she is unspayed she would be getting very hormonal now. One of my rescue girls has been fine waiting a bit longer as hers was delayed but she is now getting very huffy and grumpy.
Health concerns are something to also look at, is she eating normally, plenty of hay and fresh greens ?

It sounds to me like she’s upset that you’re not around as much. My buns are very sensitive to schedule interruptions or changes, and a free reign to 21 cage hours a day is a big one. If you really can’t spend as much time with her, I think a mate would be welcomed, so long as they have a ton of room and you’re confident in the time/work/money commitment to bonding them.

If the bed peeing is the only issue, it seems a small expense for an ex pen or something tall to block her might be worth it? Sounds like her quarters are bunny proofed, perhaps just actively preventing her from getting to certain areas is the right idea.

Hi (my first time on this forum )

I had a bunny which sounds like a similar situation to your little one. He was such a bad-tempered soul that we nicknamed him Grumpy and now he isn’t known by any other name Anyway, long story short I had to move house and his free-range became limited to a smaller area in my new home and this caused him to become quite agitated and, well, grumpy! I ended up getting a second bunny (a female) so he would have someone to play with but it definitely took a lot of work re: co-playing and ‘supervised visits’ at first as he was extremely territorial of ‘his house’ and me.

I don’t know if this is of assistance but just wanted to share my story as it sounds a bit similar to what you are dealing with. I guess if you are happy to spend time bonding them, then they will be fine. I read that a male and female (both neutered) is the best pairing (but people on this forum may suggest otherwise?).